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Name: Yang Gong
Department: CENTRAL LABORATORY
Title:Professor

 
 
 
Education & Professional Experience   2010- Professor, Cancer Research Laboratory, Fudan University Cancer Hospital.

2008-2010 Assistant Professor, Department of Pathology, The University of Texas, Houston, Texas, USA.

2005-2008 Instructor, Department of Pathology, The University of Texas, Houston, Texas, USA.
2002-2005 Postdoctoral Fellow, Department of Pathology, The University of Texas, Houston, Texas, USA.

2001-2002 Postdoctoral Fellow, Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, USA

1998-2001 Ph.D. Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
 
 
Specialty   Breast cancer, ovarian cancer, cervical cancer
 
 
Research   Cancer Biology
 
 
Publication   1.Yang G, Rosen DG, Liu G, Yang F, Guo X, Xiao X, Xue F, Mercado-Uribe I, Huang J, Lin SH, Mills GB, Liu J. CXCR2 Promotes ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced Angiogenesis. Clin Cancer Res. 2010 May 26. [Epub ahead of print]
2.Liu G, Yang G*, Chang B, Mercado-Uribe I, Huang M, Zheng J, Bast RC, Lin SH, Liu J. Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst. 2010 Jun; 2;102 (11): 812-27. Epub 2010 May 18.
3.Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15;16(12):3171-81. Epub 2010 Apr 27.
4.Zheng J, Mercado-Uribe I, Rosen DG, Chang B, Liu P, Yang G, Malpica A, Noara H, Auersperg N, Mills GB, Bast RC, Liu J. Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment. Cell Cycle. 2010 Jan 1;9(1):140-6. Epub 2010 Jan 5.
5.Shan W, Yang G, Liu J . The inflammatory network: bridging senescent stroma and epithelial tumorigenesis. Front Biosci. 2009 Jan 1;14:4044-57.
6.Rosen DG, Yang G, Liu G, Mercado-Uribe I, Chang B, Xiao XS, Zheng J, Xue FX, Liu J. Ovarian cancer: pathology, biology, and disease models. Front Biosci. 2009 Jan 1;14:2089-102
7.Chang B, Liu G, Yang G, Mercado-Uribe I, Huang M, Liu J. REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells. Cell Cycle. 2009 Mar 1;8(5):780-6. Epub 2009 Mar 20.
8.Wang D, Zhao Z, Caperell-Grant A, Yang G, Mok SC, Liu J, Bigsby RM, Xu Y. S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. Mol Cancer Ther. 2008 Jul;7 (7):1993-2002.
9.Zhang Z, Singh M, Davidson S, Rosen DG, Yang G, Liu J. Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries. Mod Pathol. 2007 Oct; 20(10):1078-84.
10.Yang G, Rosen DG, Colacino JA, Mercado-Uribe I, Liu J. Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells. Oncogene. 2007 Mar 1; 26(10): 1492-8.
11.Young TW, Mei FC, Rosen DG, Yang G, Li N, Liu J, Cheng X. Up-regulation of Tumor Susceptibility Gene 101 Protein in Ovarian Carcinomas Revealed by Proteomics Analyses. Mol Cell Proteomics. 2007 Feb; 6(2): 294-304.
12.Yang G, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, Bast RC Jr, Zhou C, Liu J. Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Carcinogenesis. 2007 Jan; 28(1): 174-82.
13.Rosen DG, Mercado-Uribe I, Yang G, Bast RC Jr, Amin HM, Lai R, Liu J. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. 2006 Dec 1; 107(11): 2730-40.
14.Wen XF, Yang G, Mao W, Thornton A, Liu J, Bast RC Jr, Le XF. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.
Oncogene. 2006 Nov 2; 25(52): 6986-96.
15.Yang G, Rosen DG, Zhang Z, Bast RC Jr, Mills GB, Colacino JA, Mercado-Uribe I, Liu J. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44): 16472-7.
16.Rosen DG, Yang G, Deavers MT, Malpica A, Kavanagh JJ, Mills GB, Liu J. Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. Cancer. 2006 May 1; 106(9): 1925-32.
17.Rosen DG, Yang G*, Bast RC Jr, Liu J. Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer. Methods Enzymol. 2005; 407: 660-76.
18.Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem. 2005 Nov 25; 280(47): 39485-92.
19.Rosen DG, Yang G, Cai KQ, Bast RC Jr, Gershenson DM, Silva EG, Liu J. Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1): 632-7.
20.Young TW, Mei FC, Yang G, Thompson-Lanza JA, Liu J, Cheng X. Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res. 2004 Jul 1; 64(13): 4577-84.
21.Liu J, Yang G, Thompson-Lanza JA, Glassman A, Hayes K, Patterson A, Marquez RT, Auersperg N, Yu Y, Hahn WC, Mills GB, Bast RC Jr. A genetically defined model for human ovarian cancer. Cancer Res. 2004 Mar 1; 64(5): 1655-63.
22.Ehrenman K, Yang G, Hong WP, Gao T, Jang W, Brock DA, Hatton RD, Shoemaker JD, Gomer RH. Disruption of aldehyde reductase increases group size in dictyostelium. J Biol Chem. 2004 Jan 9; 279(2): 837-47.
23.Yang G, Cai KQ, Thompson-Lanza JA, Bast RC Jr, Liu J. Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated small interfering RNA against Her-2/neu gene expression. J Biol Chem. 2004 Feb 6; 279(6): 4339-45.
24.Yang G, Thompson JA, Fang B, Liu J. Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer. Oncogene. 2003 Aug 28; 22(36): 5694-701.

* Co-first author.
 
 
Awards:   N/A
 
 
Out-patient Schedule  

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