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Name: Hu Zhen
Department: BREAST SURGERY
Title:Associate Professor

 
 
Education & Professional Experience   2008~present: Associate professor, Department of Breast Surgery, Cancer Hospital/Cancer Institute, Fudan University, Shanghai, China 
2003-2008: Attending of breast surgery, Department of Breast Surgery, Cancer Hospital/Cancer Institute, Fudan University, Shanghai, China  
2000~2003: Resident of surgery, Cancer Hospital/Cancer Institute, Fudan University, Shanghai, China 
2000-2003: Postgraduate Course on Surgical Oncology, Cancer Hospital/Cancer Institute, Fudan University, Shanghai, China  
1998-2000: Resident of surgery, Shanghai Pulmonary Hospital, Shanghai, China
1996-1998: Postgraduate Course on Surgery, Shanghai Medical University, Shanghai, China 
1991-1996: Bachelor of Medicine (M.D. Equivalent), Shanghai Medical University, Shanghai, China 
 
 
Specialty   Surgery and adjuvant systemic treatment of breast cancer, including oncoplastic surgery and immediate breast reconstruction.
 
 
Research   The focus of the research work is genetic testing and cancer prevention in Chinese hereditary breast cancer patients, including the mutation screening in high risk population and functional analysis in predisposing genes.

Grant and Foundation
1. The functional analysis and screening of PALB2 gene mutation in Chinese BRCA1/2 negative breast cancer families. Shanghai Rising-Star Program. 150,000 RMB. 2008.7~2010.7. Principle Investigator.
2. The study of Chinese hereditary breast cancer associated gene. The Youth Foundation of Shanghai bureau of health. 15,000 RMB. 2008.1~2010.12. Principle Investigator.
3. The localization and functional analysis of disease susceptible genes in BRCA1/2 negative familial breast cancer. Shanghai Municipal Natural Science Foundation. 50,000 RMB. 2007.12~2009.11. Principle Investigator.
4. The study of Chinese hereditary breast cancer associated gene. The Launch Foundation of Cooperation of Fudan University affiliated Cancer Hospital. 70,000 RMB. 2006.6~2009.6. Principle Investigator.
5. The correlation between CYP2D6 gene polymorphisms and efficacy of tamoxifen used in the adjuvant endocrine therapy of breast cancer. Young Investigator Award of Fudan University. 40,000 RMB. 2005.9~2007.9. Principal Investigator.
6. The collection, preserve and utilization of hereditary predisposing breast cancer cases. Foundation of Fudan University affiliated Cancer Hospital. 5,000 RMB. 2004.1~2005.12. Principal Investigator.
 
 
Publication   1. Hu Z, Song CG, Lu JS, Luo JM, Shen ZZ, Huang W, Shao ZM. A Multigenic study on Breast Cancer Risk Associated with Genetic Polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 Negative Shanghai Women with Early Onset Breast Cancer or Affected Relatives. Journal of Cancer Research and Clinical Oncology. 2007; 133 (12): 969–978.
2. Hu Z, Wu J, Liu CH, Lu JS, LuoJM, Han QX, Shen ZZ, Shao ZM. The analysis of BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives. Hum Mutat. 2003; 22 (1): 104.
3. Li WF, Hu Z, Rao NY, Song CG, Zhang B, Cao MZ, Su FX, Wang YS, He PQ, Di GH, Shen KW, Wu J, Lu JS, Luo JM, Liu XY, Zhou J, Wang L, Zhao L, Liu YB, Yuan WT, Yang L, Shen ZZ, Huang W, Shao ZM. The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified. Breast Cancer Res Treat. 2008; 110 (1): 99-109.(co-first author)
4. Rao NY, Hu Z, Yu JM, Li WF, Zhang B, Su FX, Wu J, Shen ZZ, Huang W, Shao ZM. Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients. Breast Cancer Res Treat. 2009; 116 (3): 563-570. (co-first author)
5. Rao NY, Hu Z, Li WF, Huang J, Ma ZL, Zhang B, Su FX, Zhou J, Di GH, Shen KW, Wu J, Lu JS, Luo JM, Yuan WT, Shen ZZ, Huang W, Shao ZM. Models for predicting BRCA1 and BRCA2 mutations in Han Chinese familial breast and/or ovarian cancer patients. Breast Cancer Res Treat. 2009; 113 (3): 467-477. (co-first author)
6. Cao AY, Huang J, Hu Z, Li WF, Ma ZL, Tang LL, Zhang B, Su FX, Zhou J, Di GH, Shen KW, Wu J, Lu JS, Luo JM, Yuan WT, Shen ZZ, Huang W, Shao ZM. The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives. Breast Cancer Res Treat. 2009; 114 (3): 457-462. (co-first author)
7. Cao AY, Huang J, Hu Z, Li WF, Ma ZL, Tang LL, Zhang B, Su FX, Zhou J, Di GH, Shen KW, Wu J, Lu JS, Luo JM, Yuan WT, Shen ZZ, Huang W, Shao ZM. Mutation analysis of BRIP1/BACH1 in BRCA1/ BRCA2 negative Chinese women with early onset breast cancer or affected relatives. Breast Cancer Res Treat. 2008 May 16. [Epub ahead of print](co-first author)
8. Song CG, Hu Z, Wu J, Luo JM, Shen ZZ, Huang W, Shao ZM. The Prevalence of BRCA1 and BRCA2 Mutations in Chinese Women with Breast Cancer. Journal of Cancer Research and Clinical Oncology. 2006; 132 (10): 617-626.(co-first author)
9. Huang O, Wang L, Shen K, Lin H, Hu Z, Liu G, Wu J, Lu J, Shao Z, Han Q, Shen Z. Breast cancer subpopulation with high risk of internal mammary lymph nodes metastasis: analysis of 2,269 Chinese breast cancer patients treated with extended radical mastectomy. Breast Cancer Research and Treatment 2007; 107 (3): 379-87.
10. Liu GY, Lu JS, Shen KW, Wu J, Chen CM, Hu Z, Shen ZZ, Zhang TQ, Shao ZM. Fiberoptic ductoscopy combined with cytology testing in the patients of spontaneous nipple discharge. Breast Cancer Research and Treatment 2007; 108 (2): 271-7.
11. Hu Z, Li WF, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao Lin, Song CG, Lu JS, Wu J, Di GH, Shen KW, Han QX, Shen ZZ, Huang W, Shao ZM. National Medical Journal of China. 2008 Sep; 88 (34): 1-4. Chinese
12. Hu Z, Li WF, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao Lin, Song CG, Lu JS, Wu J, Di GH, Shen KW, Han QX, Shen ZZ, Huang W, Shao ZM. 5589del8: the recurrent mutation of BRCA1 gene in Chinese breast cancer patients. Chinese Journal of Medical Genetics. 2007 Aug; 24 (4): 378-81. Chinese.
13. Hu Z, Li WF, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao Lin, Yang WT, Lu HF, Lu JS, Wu J, Di GH, Shen KW, Han QX, Shen ZZ, Huang W, Shao ZM. The difference between Chinese BRCA1 gene mutation associated breast cancer and sporadic one: the comparative study of pathologic and immunophenotypic characteristics. Chinese Journal of Surgery. 2007; 45: 489-90. Chinese.
14. Li WF, Hu Z, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao L, Liu YB, Yuan WT, Shen ZZ, Huang W, Shao ZM. BRCA1 germ line mutations in Chinese early-onset breast cancer patients. Chinese Journal of Medical Genetics. 2007 Oct; 24 (5):499-504. Chinese.(co-first author)
15. Li WF, Hu Z, Liu XY, Zhang B, Cao MZ, Wang YS, Zhao L, Liu YB, Yuan WT, Shen ZZ, Huang W, Shao ZM. BRCA1 1100delAT is a recurrent mutation in Chinese women with familial breast cancer. National Medical Journal of China. 2007 Jan 9; 87 (2): 76-80. Chinese.(co-first author)
16. Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM. CHEK2 c.1100delC may not contribute to genetic background of hereditary breast cancer from Shanghai of China. Chinese Journal of Medical Genetics. 2006 Aug; 23(4):443-5. Chinese. (Corresponding author)
17. Hu Z, Wu J, Lu JS, Luo JM, Han QX, Shen ZZ, Shao ZM. Analysis of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives. Chinese Journal of Oncology. 2004 Nov; 26 (11): 657-9. Chinese.
18. Hu Z, Zhang YK, Zhu TY, Wang GM, Shi LS, Li XQ. Telomerase activity and evolution of renal cell carcinoma. China Oncology. 2000, 10: 35~6. Chinese.
19. Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM. BRCA1 and BRCA2 gene mutations of familial breast cancer from Shanghai in China. Chinese Journal of Medical Genetics. 2006 Feb; 23 (1): 27-31. Chinese.
20. Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM. Prevalence of Val158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer. Chinese Journal of Surgery. 2006; 44 (19): 1310-1313. Chinese.
21. Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM. Effect of R264C polymorphism in CYP19A1 gene on BRCA1/2-negative hereditary breast cancer from Shanghai population of China. Chinese Journal of Medical Genetics. 2006 Apr; 23 (2):181-3. Chinese.
22. Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM. ER-α gene polymorphisms and the risk of non-BRCA1/2 hereditary breast cancer. Chinese Journal of General Surgery. 2006, 21: 637~40. Chinese.
23. Liu GY, Chen CM, Hu Z, Lin H, Shen KW, Shen ZZ, Shao ZM. Stereotactic biopsy for non-palpable breast lesions: evaluation and choice of minimal invasive and excisional biopsy. Chinese Journal of Surgery. 2006, 44: 1322-4. Chinese.
24. Huang O, Lin H, Shen KW, Wang LP, Hu Z, Liu GY, Wu J, Lu JS, Shao ZM, Han QX, Shen ZZ. High risk factors of intramammary lymphatic metastasis in breast cancer patients received extended radical mastectomy:an analysis of 1679 cases. Chinese Journal of Practical Surgery. 2006, 26: 270-4. Chinese.
25. Song CG, Hu Z, Yuan WT, Di GH, Shen ZZ, Huang W, Shao ZM. Mutational analysis of BRCA1 and BRCA2 genes in early-onset breast cancer patients in Shanghai. National Medical Journal of China. 2005 Nov 16; 85 (43): 3030-4. Chinese.
26. Hu Z, Shen ZZ. Heart side effect of adjuvant therapy for early breast cancer. China Prescription Drug. 2005, 5: 23~6. Chinese.
27. Shen KW, Hu Z. Diagnosis and Differentiation of Breast Lumps. Chinese Journal of Practical Surgery. 2005, 25: 110~2. Chinese.
28. Shao ZM, Hu Z, Xu CR. Predict the Effect of Neoadjuvant Chemotherapy of Breast Cancer by cDNA Microarray. The Journal of Evidence-Based Medicine. 2005, 5: 18~20, 25. Chinese.
29. Hu Z, Shen ZZ, Shao ZM. The interrelationship of BRCA1 and BRCA2 gene mutation in the survey and prevention of breast cancers. Journal of Clinical Medicine in Practice. 2003, 7: 121~3. Chinese.
30. Hu Z, Shao ZM, Shen ZZ. Familial Breast Cancer. Journal of Surgery Concepts & Practice. 2001, 6: 419~21. Chinese.
31. Hu Z, Shen KW, Shen KW. Research advances of National Surgical Adjuvant Breast and Bowel Project breast cancer trials. China Oncology. 2001, 11: 550~7. Chinese.
 
 
Awards   1. 2008: Shanghai Rising-Star Program
2. 2007: The first price of the excellent article in the 9th Chinese Breast Cancer Conference.
3. 2006: The “Tian-Hen Cup” first price of Fudan University affiliated cancer hospital.
4. 2005: The “Tian-Hen Cup” third price of Fudan University affiliated cancer hospital.
5. 2003: The “Three-Gun Cup” award of Shanghai Association of Inventions.
6. 2002: UICC (International Union Against Cancer) ICRETT (International Cancer Technology Transfer) fellowship. Study at UCLA Medical School/Relvon Breast Cancer Center.
 
 
Out-patient Schedule  

Monday Afternoon