Department: Cancer Research Institute
Title:Associate professor, Principle Investigator

Education & Professional Experience   Dr. LI graduated from China Medical University with her MD degree and underwent research training at Kanazawa University in Japan, received her Ph.D. She was as the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship and has two years postdoctoral training experiences in Kanazawa University in Japan. She joined in Fudan University Shanghai Cancer Center as an associate professor and Principle Investigator at Cancer Research Institute from October 2009.
Specialty   Cancer molecular bioregulation, Tumor microenvironment, Tumor metastasis
Research   Dr. LI research program focuses on the regulation network of a novel serine/threonine kinase, Pim-3, in human various type of cancers and develop the molecular targeting therapy, as well as the roles of microenvironment in human carcinogenesis and metastasis. The research results were published in Cancer Research,The Journal of Immunology, Oncogene, Oncotarget, Molecular Cancer Research, Cancer Science, International journal of cancer et al. The research work was supported by the National Science Foundation of China (NSFC) (30973476, 812727, 81472223), the Shanghai Pujiang Program (KW201028464).
Publication   *Corresponding author # First author
1. Liang C, Yu XJ, Guo XZ, Sun MH, Wang Z, Song Y, Ni QX, Li HY, Mukaida N, Li Ying-Yi*. MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine. Oncotarget 2015
2. Liang C, Wang Z, Wu L, Wang C, Yu BH, Yao XZ, Wang XL, Li Ying-Yi *. Combined application of caerulein and dimethylbenzanthracene induced orthotopic inflammation-related pancreatic carcinogenesis in a wild-type mouse. Tumor Bio. 2015.
3. Liang C and Li Ying-Yi*. Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy Molecular Medicine Reports 2014
4. Liu B, Wang Z, Li H-Y, Zhang B, Ping B, Li Ying-Yi*. Pim-3 promotes human pancreatic cancer growth by regulating tumor vasculogenesis. Oncology Reports 2014
5. Li Ying-Yi# and Naofumi Mukaida. Pathophysiological roles of Pim-3 kinase in pancreatic. World J Gastroenterol 2014
6. Zhang F, Liu B, Wang Z, Yu XJ, Ni QX, Yang WT, Mukaida N, Li Ying-Yi*. A novel regulatory mechanism of pim-3 kinase stability and its involvement in pancreatic cancer progression. Mol Cancer Res 2013
7. Wang C, Li HY, Liu B, Huang S, Wu L, Li Ying-Yi*. Pim-3 promotes the growth of human pancreatic cancer in the orthotopic nude mouse model through vascular endothelium growth factor. J Surg Res 2013
8. Shang K, Bai Y, Wang C, Wang Z, Gu H, Du X, Zhou X, Zheng C, Chi Y, Mukaida N, Li Ying-Yi*. Crucial Involvement of Tumor-Associated Neutrophils in the Regulation of Chronic Colitis-Associated Carcinogenesis in Mice. PLoSONE 2012
9. Wang Z, Li X, Shang K, Zhang P, Wang C, Xin Y, Zhou L and Li-Ying-Yi*. T-18, a stemonamide synthetic intermediate inhibits Pim kinase activity and induces cell apoptosis as potent anticancer drug. Oncology Reports 2012
10. Li Ying-Yi#, Kawakami T., Wang Ying-Ying, Baba T., and Mukaida N. The Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability. International Journal of Cancer 2010
11. Li Ying-Yi#, Wu Yu, Tsuneyama K., Baba T., and Mukaida N. Essential Contribution of Ets-1 to constitutive Pim-3 Expression in Human Pancreatic Cancer Cells. Cancer Science, 2009
12. Li Ying-Yi#, Popivanova B.K., Nagai Y., Ishikura H., Fujii C., and Mukaida N., Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to counteract Bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Research, 2006
13. Li Ying-Yi#, Aoki T., Mori Y., Ahmad M., Miyamori H., Takino T. and Sato H., Cleavage of Lumican by Membrane-Type Matrix Metalloproteinase-1 Abrogates This Proteoglycan-Mediated Suppression of Tumor Cell Colony Formation in Soft Agar. Cancer Research, 2004
14. Wu Yu, Li Ying-Yi, Matsushima K., Baba T., and Mukaida N. CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts, and their angiogenic molecule expression in murine lung metastasis process. The Journal of Immunology, 2008
Awards   July 6, 2006 Japan Hokkoku Newspapers 《Regulating pancreatic cancer cell proliferation gene discovered -Drugs, expect the development of therapeutics》
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